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Arginine Pyroglutamate and Lysine Improve Growth Hormone (GH) levels: Arginine stimulates the natural release of growth hormone and is a far safer and more cost effective alternative to growth hormone treatment such as HGH injections. Growth hormone is one of the most powerful hormones in the human body which promotes the growth of lean muscle tissue and the loss of fat. As you age, growth hormone levels drop, which is one reason you lose muscle and gain fat. In a controlled trial, when arginine and other amino acids were combined with weight training, a greater decrease in body fat was obtained after only five weeks than when the same exercise was combined with a placebo. Arginine is also needed to increase protein synthesis, which can in turn increase muscle growth.
L-arginine taken on an empty stomach can cause a significant release of growth hormone in many people. A dosage of between 10 and 30 grams of L-Arginine, depending upon factors such as age and body weight, is needed to have any impact on GH release. Taking arginine in capsule form is not recommended because it would take upwards of 20 capsules per serving to have a substantial impact on GH, which is why powder is the recommended delivery method. However, research shows that when arginine pyroglutamate is combined with lysine the dosage of arginine drops dramatically. Just 1200mg of each nightly has been shown to substantially increase GH.
Growth Hormone (GH) for the athlete: Athletes involved in intense exercise on a regular basis need Growth Hormone (GH) to increase energy, enhance lean body mass and to maintain strong bones and keep their weight under control. Availability of GH in systemic circulation also helps increase strength, burn fat, enhance libido, boost immunity and support tendons and ligaments. By inducing the secretion of GH from the pituitary, arginine and lysine stimulate muscle metabolism and, hence, provide nutritional support for the athlete.
Research shows Arginine Pyroglutamate and L-Lysine may improve GH levels: The combination of Arginine Pyroglutamate with L-lysine is one of the first natural GH releasers proven by scientific research to work. L-Arginine L-Pyroglutamate was the focus of world-wide attention in 1981 when Italian researcher A. Isidori, M.D., and his colleagues of the University of Rome determined that a combination of L-Lysine and L-Arginine L-Pyroglutamate when given orally to a group of 15 male volunteers between the ages of 15 and 20 was more than 10 times more effective at increasing blood levels of human growth hormone than taking only the amino acid L-Arginine by itself (yielding a average net GH increase of more than 700%). According to these researchers, we could demonstrate that the association of the two amino acids does result in the release of biologically active GH able to affect peripheral cellular receptors and thus cell growth in general.
One reason this combination might be so effective is that free form L versions of Lysine and Arginine compete for the same receptors. Replacing L-arginine with Arginine Pyroglutamate prevents competition for the same receptors. It is suggested that Arginine Pyroglutamate attaches to a different receptor allowing for a synergistic effect between the two amino acids. NutraBio's Arginine Pyroglutamate Plus Lysine combines 1200 mg of L-Arginine L-Pyroglutamate along with 1200 mg of free form L-Lysine which is the exact formula used in the university study that proved the most beneficial combination to promote GH levels.
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